Two hundred years after Mary Shelley's novel the brilliant but mad Doctor (Thomas Kretschmann) has sustained his creature and himself over two centuries through genetic experimentation. In present-day America Detective O'Connor (Parker Posey) is investigating a series of horrific murders which leads her to the doctor and his creature. What she uncovers reveals the strange evolution the doctor and his creation undergo over the course of two centuries and the divergent paths creator and monster take in pursuing good or evil. 在玛丽·雪莱的小讲两百年后，才华横溢但疯狂的大夫使他自己和他的怪物从两个世纪前的当初的实验一直幸存下来。现在，美国探员 O'Connor 在调查系列谋杀案时，被引向了大夫和他的怪物，并揭露出在长达两个多世纪的漫长岁月中，大夫和他作品间的奇特演变和他们踏上善与恶的不同道路。
